TERATOLOGICAL STUDIES OF HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE IN RATS
نویسندگان
چکیده
منابع مشابه
Morphological studies in modern teratological investigations.
Despite the variety of modern molecular techniques available, examination of foetal anatomy is still a fundamental part of teratological studies in evaluating the developmental toxicity of xenobiotics or other non-chemical factors. The article presents contemporary methods of embryotoxicity and foetotoxicity assessment. A single alizarin red S and double alcian blue followed by alizarin red S s...
متن کاملStudies on the conversion of acetate, lactate, and malonate to succinate in the intact rat.
This investigation, preliminary reports on parts of which have previously appeared (1, 2), presents data on the conversion in the intact rat of the labeled carbon of the following compounds to succinate: NaHC*03, CH&*OOH, C*H&*OOH, CH&HOHC*OOH, and C*H&*HOHCOOH. All the animals were injected with malonate to augment the urinary excretion of succinate (3). The latter was isolated from the urine ...
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Cephradine, a semisynthetic cephalosporin antibiotic, has a low order of oral and parenteral toxicity in animals. The oral LD(50) in mice and rats ranged from 5 to >8 g/kg, and the intraperitoneal LD(50) values in mice and rats were 0.7 to 1.5 g/kg and 4.0 g/kg, respectively. The intravenous LD(50) in mice ranged from 3.0 to 3.8 g/kg. In anesthetized dogs, intravenous doses of cephradine (40 an...
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The rate of excretion of C1402 has been followed after the intraperitoneal injection into rats of (1) isotopic bicarbonate, NaHC1403, (2) isotopic acetate, CH3C1400Na, and (3) isotopic succinate, Na00CCH&HzC1400Na. The data so obtained yield information on the rate at which CO2 participates in the metabolic processes of the body, as well as the rate at which isotopic carbon is eliminated follow...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1985
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.10.supplementii_203